What is the K-Pharmacy Universe series?
K-Pharmacy Universe is a content series that guides anyone unfamiliar with Korean pharmacies and their beauty products. From unique items found only in Korea to insider tips known mostly to locals, we share verified information from a Korean perspective.
In previous parts, we introduced the hottest Korean pharmacy skincare products of 2025 and how to use them together to achieve the best results.
[블로그] K-Pharmacy Universe | Part 1: Top 5 Skincare Products at Korean Pharmacies in 2025
[블로그] K-Pharmacy Universe | Part 2: Top Korean Pharmacy Products to Bring Home as Souvenirs
What is PDRN?
PDRN (Polydeoxyribonucleotide) is a regenerative ingredient extracted from salmon DNA. Simply put, it’s a DNA-based component that helps promote cell regeneration.
Why PDRN Is Special
- Boosts cell regeneration: Speeds up the recovery of damaged skin cells
- Stimulates blood vessel growth: Improves nutrient delivery through new capillaries
- Reduces inflammation: Calms skin irritation and inflammatory responses
- Supports collagen synthesis: Helps improve skin elasticity and structure
Clinically Recognized in the Medical Field
PDRN was originally used as a medical injection before gaining popularity in skincare. In Korean dermatology, it has been used for several years to treat:
- Scar treatment: Improves acne scars and post-surgery scars
- Wound recovery: Promotes regeneration after laser procedures
- Skin regeneration: Restores elasticity in aging skin
- Atopic dermatitis care: Repairs and strengthens the damaged skin barrier
Scientifically Proven Benefits of PDRN
Clinical data shows the effects of PDRN at a concentration of 1,200 ppm. While higher PDRN concentrations do speed up cell recovery, clinical tests on dermal and epidermal wound healing show that anything above 1,300 ppm doesn’t provide additional benefits. In other words, more isn’t always better!
PDRN Checklist
- Optimal concentration: 1,000–1,200 ppm is the sweet spot
- Formulation: Choose a product that suits your skin type
- Safety: Make sure it’s clinically tested
- Combination ingredients: Check if it includes other ingredients that enhance PDRN’s effects
The Perfect PDRN Starter Product: Rejuall
- Proven concentration: 1,200 ppm, the optimal level
- Gel formulation: Suitable for all skin types
- Synergistic ingredients: Includes hyaluronic acid, collagen, and more
- Clinically tested: Scientific data supports its effectiveness
If you want to experience the benefits of PDRN or gift it to someone, Rejuall is a great choice. In just four months after its launch, it sold 250,000 units!
Check out more about the Korean pharmacies below!
FAQ
Q. I heard PDRN is extracted from salmon. Is there any risk of allergy?
A: PDRN is a pure nucleic acid ingredient with all proteins completely removed from salmon DNA. It’s different from salmon allergens, so allergic reactions are extremely rare. However, if you have sensitive skin, it’s best to do a patch test before use.
Q. When is the best time to use PDRN products?
A: PDRN supports cell regeneration, so it’s most effective at night when your body’s repair activity is highest. You can use it in the morning too, but nighttime application is recommended.
Q. Can I use it with other skincare ingredients?
A: Yes! PDRN works well with most ingredients, especially hyaluronic acid, collagen, and niacinamide, for added benefits. Avoid using it simultaneously with strong acids like AHA or BHA—use those at different times of the day.
Q. Is it safe to use during pregnancy or breastfeeding?
A: PDRN is naturally derived and generally safe as a topical product. However, it’s always best to consult your doctor if you are pregnant or breastfeeding.
Q. How long until I see results?
A: It varies, but most people notice improvements after 4–6 weeks of consistent use. For wound or scar care, visible changes can appear within 1–2 weeks, while overall skin improvements may take longer.
Q. PDRN is more expensive than regular pharmacy items. Is it worth it?
A: Yes! PDRN requires a complex extraction and purification process, which makes it higher cost. However, compared to medical injection treatments, you can achieve similar benefits at home for about one-tenth of the price, making it very cost-effective.
Q. Is PDRN safe for sensitive skin?
A: Absolutely. PDRN helps restore the skin barrier, which is beneficial for sensitive skin. Gel-type products like Rejuall are low-irritation, so even sensitive skin can use them safely. Start with a small amount to test your skin’s reaction.
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