When it comes to cosmetic treatments in Korea, Rejuran Skin Booster is often one of the first names that comes up. Known for its skin-rejuvenating effects, it’s a go-to for those looking to improve texture, elasticity, and overall skin health.
But did you know there’s more than just one type of Rejuran? In fact, there are at least four different kinds: each with unique ingredients and benefits designed for specific skin concerns.
Interestingly, the Rejuran used in Korea is also different from the version commonly offered in the U.S. So what exactly sets them apart? And which type of Rejuran is right for you? Keep reading to learn everything you need to know.
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What is Rejuran Treatment?
Rejuran is a Korean regenerative skincare brand known for its range of products, including skincare lines, Skin Boosters, and water-light injections—used both in medical aesthetics and for at-home care. Recently, it has become hugely popular in Korea and across Asia, with the “repair water-light injection” as its signature treatment.
Traditional skin booster injections mainly focus on moisturizing and hydration, with hyaluronic acid as the key ingredient. In contrast, Rejuran Skin Booster works by activating your skin’s natural self-repair process. Its main ingredients include PDRN extracted from salmon sperm and PN from salmon milt.
Official data shows that salmon DNA shares up to 99% similarity with human cells. This makes it highly effective for boosting skin regeneration, reducing inflammation, and repairing damaged skin. Thanks to these benefits, Rejuran has become one of the most popular skin-nourishing and hydrating treatments in the medical beauty industry in recent years.
How Rejuran Injections Are Done?
Rejuran injectable skin boosters can be administered in two ways: MTS (Microneedle Therapy System) and manual injection by a skilled practitioner. Besides differences in pain levels, these methods also vary in how deep the injection goes, their effectiveness, and the recovery time.
MTS (Microneedle Therapy System) typically involves devices like water light guns or microneedling tools that quickly and continuously deliver the medication by gently pricking the skin. This method is fast and causes minimal pain so the discomfort is usually quite manageable.
However, since machines can’t always control injection depth precisely and there’s a risk of medication leakage, if you’re serious about beauty and don’t mind a little discomfort, manual Rejuran injections are usually the better choice.
Manual injections, on the other hand, are done by doctors who inject carefully point by point. This allows them to adjust the depth and dosage based on your skin’s condition, so the treatment targets the dermis more precisely, leading to more noticeable and focused results.
However, this method depends a lot on the doctor’s skill. Even with anesthesia, you might still feel some stinging during the procedure. Afterward, mild swelling and bruising are common and can last a few days, so manual injections aren’t ideal if you have important events coming up right after treatment.
Types of Rejuran Injections
There are currently four common types of medical-grade injectable Rejuran. Each differs slightly in ingredients, packaging, and treatment areas. They’re often identified by the color of their boxes.
1. Rejuran Healer (리쥬란 힐러)
Also called the “Rejuran Black Box,” this is the classic and most well-known version. This is usually the one that comes to mind first when people hear "Rejuran Injection".
Each box contains two vials (2cc each) with a high 2% concentration of PN, specially formulated for deep skin repair and overall quality improvement. Beyond basic hydration, it effectively heals damaged skin and fades acne scars—earning it the nickname “all-purpose skin booster” at many medical aesthetic clinics.
However, the treatment can be quite painful. Even with numbing cream, you might still feel stinging or tear up during the procedure.
2. Rejuran HB (리쥬란 HB플러스)
Also known as the “Rejuran Red Box,” this version contains one vial (1cc) and combines 1% PN with 1% hyaluronic acid as its main ingredients.
It features an advanced formula designed to deeply hydrate and brighten the skin, perfect for those with dull or dry skin looking for a radiant, dewy glow.
It’s also the only Rejuran product that includes a built-in anesthetic, which helps reduce the stinging sensation during injections. If you’re sensitive to pain or trying Rejuran for the first time, the Red Box is a great option to start with.
3. Rejuran I (리쥬란 아이)
Also known as the “Rejuran White Box” or “Rejuran I Booster,” this version comes with one syringe (1cc) and contains 1% PN along with a blend of active ingredients. It’s specially formulated for the delicate skin around the eyes.
In terms of formulation, the Rejuran White Box can be seen as a lighter version of the Black Box. It has a thinner texture and lower viscosity, making it ideal for delicate areas with thinner skin, especially around the eyes.
This version not only hydrates and firms the eye area but also helps improve dryness and reduce fine lines. If your main concerns are dark circles or fine wrinkles, the White Box offers a gentle yet effective solution.
4. Rejuran S (리쥬란 에스)
Also known as the “Rejuran Blue Box,” this version contains one vial (1cc) and includes 1% PN. Among all the Rejuran skin boosters, it has the thickest consistency.
The Rejuran Blue Box is formulated with added anti-inflammatory ingredients and a low-irritation formula, making it especially suitable for sensitive skin and for repairing deep acne scars or skin indentations.
If you’re dealing with concerns like oily skin imbalance, acne marks, enlarged pores, or rough texture, Rejuran S (Blue Box) offers more targeted results compared to other Rejuran types.
Rejuran Healer (Black Box) | Rejuran HB (Red Box) | Rejuran I (White Box) | Rejuran S (Blue Box) | |
Ingredients | 2% PN | 1% PN + 1% Hyaluronic Acid + Anesthetic | 1% PN + Multiple Active Ingredients | 1% PN + Anti-inflammatory Factors |
Main Effects | Enhances skin's overall repairing ability | Moisturizing & brightening | Reduces dark circles Brightening | Improves acne scars Deep repair |
Injection | Whole face Manual/Machine injection | Whole face Manual/Machine injection | Eye area Manual injection | Localized injection Manual injection |
Suitable For | Improve skin condition Those not afraid of pain | Dry skin Pain sensitive | Improve fine lines Delay early aging | Oily skin Obvious acne scars |
Side Effects
Although the main ingredient PN in Rejuran Water Glow Injections is highly biocompatible (and certified by both the Korean KFDA and the European CE) some formulations may cause facial swelling that lasts 1 to 3 days after treatment. Be sure to factor this in when planning your travel or treatment schedule.
Since everyone’s skin reacts differently, mild side effects like redness, swelling, bruising, or even allergic reactions can still occur.
While there’s no need to worry too much, it’s important to get a proper pre-treatment assessment, choose a trusted and professional clinic, and check for any sensitivity or allergy risks beforehand to help minimize potential side effects.
Rejuran in the U.S. vs South Korea
As of July 2025, Rejuran is not officially FDA-approved for medical use in the United States. While some clinics may offer Rejuran treatments through private importation, these products are not regulated by the FDA, which means their safety and authenticity cannot be fully guaranteed. Consumers should be cautious and thoroughly research any clinic offering Rejuran injections to avoid unlicensed or counterfeit treatments.
Rejuran products available in the U.S. are mostly limited to topical forms like creams or serums, which can be used alongside microneedling or laser treatments but do not involve injections into the skin. The injectable form of Rejuran, which is widely used and approved in South Korea, involves injecting polynucleotides derived from salmon DNA directly into the dermis to promote skin regeneration and healing.
For those seeking the full benefits of injectable Rejuran, traveling to South Korea remains the safest and most effective option. As regulations evolve, it’s important to stay updated on any changes in FDA approvals related to Rejuran treatments in the U.S.
Recommended Skin Clinics for Rejuran
Rejuran injection is one of the most popular treatments at Korean skin clinics, and you’ll find it offered at nearly all major locations. That said, because it involves dermal injections, it’s important to compare clinics and check real reviews to feel confident about your choice.
To help you get started, we’ve rounded up a few well-reviewed clinics that offer Rejuran treatments. If you're interested, click through to read the reviews and find the clinic that best fits your needs!
[스팟] ✨Creatrip Pick✨ DIORE CLINIC | Free Reservation, Online Consultation Available
[스팟] Popular K-Beauty TreatmentsㅣnBOM Clinic
[스팟] PROJECT U CLINIC
[스팟] Cheongdam Monet Clinic | Medical Aesthetic
[스팟] YONSEIRO CLINICㅣPetite Skin Procedures
[스팟] Xenia Clinic | Foreigner-Friendly Skincare Treatment Clinic in Gangnam
[스팟] Onlif Clinic | Petite Skin Procedures
[스팟] Medicube Clinic Gangnam Branch | Gangnam Skincare Clinic
Thinking about getting a skin procedure in Korea?
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That’s a wrap up of our guide to Rejuran in Korea. Hopefully, you now have a clearer understanding of the differences between each type and what to expect. Getting Rejuran treatments in Korea is not only affordable but also high-quality. With advanced techniques, helpful translation services, and the chance to claim a tax refund by simply showing your passport, it’s no wonder this treatment is a local favorite! If you’re thinking about getting medical treatments in Korea, be sure to keep following us for more tips and updates.
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